Acute myeloid leukemia in a father and son with a germline mutation of ASXL1

Occurrence of Secondary Acute Myeloid Leukemia in a Patient with Breast Cancer after Chemotherapy

Successful Treatment of Bilateral Pulmonary Hydatic Cysts in a Child with Acute Myeloid Leukemia

Few data are available about hydatid cysts in patients with malignancy; however, these have rarely been described in association with leukemia. The purpose of this report was to present an unusual case of coexisting leukemia and pulmonary hydatid cysts.This study presented a 13-year-old boy with acute myeloid leukemia who was diagnosed with bilateral pulmonary hydatid cysts after the completion...

Evaluation of a father and son with atypical chronic myeloid leukemia with SETBP1 mutations and a review of the literature

We report the case of a father and son diagnosed with atypical chronic myeloid leukemia (aCML). Both patients harbored SETBP1 mutations, which are present in 24.3% of aCML patients. Moreover, both shared the variant encoding p.Pro737His, but the aCML severity was greater in the son because of the presence of two other missense mutations causing p.Asp868Asn and p.Ser885Arg alterations. SETBP1 mu...

The Relationship between Mutation in HOXB1 Gene and Acute Myeloid Leukemia

Background: HOX genes are an exceedingly preserved family of homeodomain-involving transcription factors. They are related to a number of malignancies, comprising acute myeloid leukemia (AML). This study aimed to evaluate the effect of HOXB1 7bp deletion mutation on HOXB1gene expression in 36 individuals. Materials and Methods: The present cross-sectional study was done on a large Iranian fami...

Clinical and Laboratory Findings of Cup-Like Nuclei in Blasts with FLT3 Mutation in Pediatric Acute Myeloid Leukemia: A Case Report

Biologically, Acute myeloid leukemia (AML) is highly heterogenous. AML with cup-like blast morphology variant has been reported to have important role in risk group stratification and treatment implications. In pediatric age group, this morphology and its clinical implication is rarely discussed. Although this morphology variant is not stated in World Health Organization (WHO) classification of...